hand-to-hand Share definition Flag A physical exchange of drugs for money or the crime associated with this act. Van $tylez: What did you get locked up for back then? AZ: Uhhhh, hand-to-hand. hand-to-hand by funk_soul_bubby July 8, 2012 0 0 Get merch Get the hand-to-hand mug. Buy Now — $32.95 See more merch