When you cut a particularly horrific fart and then need to break up the stink somehow before someone enters your personal space.
I saw my colleague running about in there like a nut, fanning the air with his notebook and all; he was surely making an effort to deflatulate the room.
To take a problemsituation that is seemingly impossible to coordinate or rectify, and create a working solution that is satisfactory to all parties of interest.
"The Boss said to defuckulate your work backlog today, or you'll need a federal bailout for your next paycheck!"