In a tabletop game, a murderhobo is a player who murders NPCs indiscriminately. This is normally derogatory, referring to a player who totally ignores quests, dialog, backstory, trade,
world building etc.
The term is most common with Dungeons and Dragons, but it can be applied to most RPGs where the player is allowed to kill most
quest-giving NPCs and NPC traders. E.g. Elder Scrolls,
Fallout, Divinity original sin.
DM: The sad little orphan girl tugs at Steve's trenchcoat to get his attention, and ask for help saving her pet
dog from...
Steve: I'd like to
roll a strength check against strangling the orphan.
Dave: I call dibs on the
dog.
DM: You murderhobos disgust me.