The feeling one has when one has been awake for to long on a variety of substances, primarily ecstasy, cocaine, and/or crystal meth.
Dude I took my last E pill five hours ago and now I'm just straight twackered.
by Rellik Uzi August 14, 2010
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"Hey man you hear about Tom? He became a total twacker always fucked up on that fake shit.. "
by imdabessss January 17, 2013
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a user of the drug methamphetamine who has not forgotten that he/she uses methamphetamine, thereby making them somewhat immune to the paranoid delusions and hallucinations often associated with the drug
The twacker felt the person looked very familiar, but was able to dismiss the thought before saying anything due to his self-recognized "up for three days" status.
by francisco March 28, 2004
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A mix between cracker & tweaker.
When the fuck are those twackers gonna go to sleep!!!!
by Ashley June 18, 2006
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"It's only 3:00 and we've killed a twacker and a half, time to hit the store"
by bhood May 18, 2007
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