a user of the drug methamphetamine who has not forgotten that he/she uses methamphetamine, thereby making them somewhat immune to the paranoid delusions and hallucinations often associated with the drug
The twacker felt the person looked very familiar, but was able to dismiss the thought before saying anything due to his self-recognized "up for three days" status.
by francisco March 28, 2004
Get the twackermug. by Ashley June 18, 2006
Get the twackermug. 
Get the twackermug. a twelve pack of beer
by bhood June 5, 2007
Get the twackermug. Tweet: Please excuse the Viagra tweets coming from my Twitter account. I have been victimized by a twacker.
by TheDDog October 6, 2012
Get the twackermug. The feeling one has when one has been awake for to long on a variety of substances, primarily ecstasy, cocaine, and/or crystal meth.
by Rellik Uzi August 14, 2010
Get the Twackeredmug. 