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The feeling one has when one has been awake for to long on a variety of substances, primarily ecstasy, cocaine, and/or crystal meth.
Dude I took my last E pill five hours ago and now I'm just straight twackered.
Twackered by Rellik Uzi August 14, 2010

tuckered 

exhausted, tired, finished, drained, tuckered out
After that long walk she was all tuckered out.
tuckered by aphrael October 4, 2005

Thatchered 

When a woman in a conversation dominated by men, seems to be topping the men in violent rhetoric in what could be interpreted as an attempt to establish her strength and evidence of her ability/willingness to be as violent as she perceives masculine/strong leadership to be or as she believes it should be...in a similar fashion to Margaret Thatcher.
Wow, Carly Fiorina Thatchered hard last night.
Thatchered by nashfriend October 31, 2015

plumb tuckered out 

Exhausted.

Origin:
It's no surprise that 'tuckered out' is an American phrase. No 'B-feature' western from the 1930s and 1940s was complete without Gabby Hayes being 'plumb tuckered out'. Hayes' contribution to the genre was celebrated by Mel Brooks in the 1974 film Blazing Saddles. In that, a look-alike actor played the part of Gabby Johnson, spouting 'authentic frontier gibberish' - "dad gum it, I am gonna die here an' no sidewindin bushwackin, hornswaglin, cracker croaker is gonna rouin me biscuit cutter".

An example is from the Wisconsin Enquirer, April 1839:
"I reckoned to have got to the tavern by sundown, but I haven't - as I'm prodigiously tuckered out."

'Plumb tuckered out' is somewhat later and the first example is from the Cedar Rapids Evening Gazette, February 1889: "They'll get plumb tuckered out waitin."

The actual derivation of this phrase is quite prosaic. 'Tucker' is a colloquial New England word, coined in the early 19th century, meaning 'to tire' or 'to become weary'. 'Tuckered out' is just a straightforward use of that. 'Plumb' is just an intensifier. 'Tuckered out' is rarely seen alone.
"I've been on my feet all day long, I'm plumb tuckered out!"
plumb tuckered out by CajunQueen August 18, 2009

Tuckered Out 

Derived from the colloguial New England English word "tucker" of the 19th Century.
To "tucker" is to exhuast and to be "tuckered out" is to be exhausted.
I didn't get back from the bars 'til three o'clock in the morning and today I'm plumb tuckered out.
Tuckered Out by TheArithmetic January 31, 2008

tankered 

Very drunk from an excess of alcohol. A combination of the words: "tanked" + "hammered" = "tankered".
He had way too many shots - he was hangin' on everyone and slurring his words. That kid was tankered.
tankered by madmary February 25, 2009