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It comes from the Spanish pragmatism "Me la follo". In English "I want to fuck that girl" or "I like to have wild sex with this girl, but i am the forever alone guy"... more or less.
AMIGO - Mira esa tía!...
TÚ - Esta buenísima, MELAFO!
____

DUDE - Hey man, look at that girl!...
YOU - She's so good, MELAFO!
Melafo by Humin September 28, 2011
Related Words
a noun,adjective and a verb; love; the kind of love that kills you and brings you back to life again; a roller coaster ride of emotions;happiness and energy; a certain boy a certain girl
My boyfriend is my melason.
melason by adik.ako35 February 28, 2010

mellgowild

Amazingly attractive female addicted to Dr. Pepper.
male #1: "whoa, i 'seen' mellgowild !"
male #2: "you mean on Youtube ?"
male #1: "yea !"
mellgowild by hi devin October 16, 2008

melanocious

showing off your melanin or tan in a way it’s bragging.
Girl: Omg my skin looks so amazing thanks to the sun! I love being being tan!

Girl #2: Haha, you are so melanocious right now!
melanocious by Empress05 October 12, 2022

meladoodle 

The current Queen of Tumblr Textposts. Known for her massive dong.
Friend 1: "Damn son, check out this funny textpost"
Friend 2: "Oh that's a Meladoodle"
Friend 1: "Hoo dat"
meladoodle by clivepalmer September 13, 2013

melatonin 

A natural pill that not only helps you sleep but also gives you more intense vivid dreams. It also increases the chance of having a lucid dream.
That 6 mg of melatonin I took before I went to bed gave me a great nights sleep.
melatonin by TM January 8, 2005