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1 ) under the influence of some sort of substance or drug

2 ) a high
p1 ) - " man you see that dude over there ? heres off one !! " * the dude " over there " completely nodding off *
it could also be combined with other words like " hes off a good one " etc etc
Off one by 47genesis November 19, 2023
Words you can keep
To get sober. Or more commonly referred to quitting methamphetamines.
Hey, I'm sorry but I can't chill with you guys at the tweaker pad anymore...I'm trying to stay off-one for good.
Off-one by Fairyduster86 January 18, 2017

Off one's rocker

To get angry, frustrated, or irritated to the point that you suffer a tantrum of sorts
Anna: How was tennis, Tim?
Tim: Rubbish. I lost to Aidan. I should try and keep a level head and not go off my rocker when I play...
Anna: Yes. One should never go off one's rocker. Now it's time to eat some squirrel pie.
Tim: :l

off one's trump 

Unhinged; temperamentally unsuited for one's position.
The White House staff is off one's trump; they cannot give a consistent explanation for the incriminating Russian collusion stories.
off one's trump by smjgJsbjgsm August 8, 2018

Off One's Base 

adj. A person that is crazy or behaving in idiotic ways
"you are so off one's base"
Off One's Base by Get a mug April 6, 2022

Knuckling one off 

When an fat dumpy lesbian beats herself off and since she's so fat she aggressively rubs her knuckles on her puss to get off
Patti couldn't get the job done with her dildo so she ended up knuckling one off on that big fat pussy

pinch one off 

1. To quickly squeeze out a shit
2. To pinch off the end of a rather large shit in order to be done quicker.
Jerry had to pinch one off as the game started in ten minutes.
pinch one off by Anonymous April 12, 2003
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