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When a male has the defining traits that make him manly removed, typically via marriage or long term relationship to a much more dominant woman. These qualities usually include the ability to think or dress for himself, having his leisure time replaced with shopping or chores, and/or no longer having a spine.
The Kardashians have performed a successful manectomy on Bruce Jenner.

My friend was totally cool before he got engaged. Now he has to ask permission to leave the house. I think he has to stay close so that he doesn’t lose his penis, which is in a jar.
manectomy by The Salad February 26, 2010
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mastectomy

Removal of one or both a females breast due to breast cancer.
Emily: omg, why doesn't Sandra have any tits?? freak!
Morgan: Emily, stop being a bitch! She has breast cancer. She needed to have mastectomy surgery to remove her tits.
Emily: ohh, sorry Sandra. =/
mastectomy by crazyyyyyychic November 25, 2007

Involuntary mastectomy

A form of breast reduction or removal. Usually performed by an unlicensed surgeon using a machete in a dark room with no anaesthesia.
You can watch how to perform an involuntary mastectomy on your girl if you pick up Tears of the sun.
The act of removing an over grown man child from his over bearing Mom.
Guy 1: "Yo did you know Dave still lives at home with his Mom. She makes his bed in the morning and cooks him meatloaf."

Guy 2: "Thats crazy. Dave is 28 years old! We need to perform a momectomy and get Dave his own apartment!"
momectomy by Innate October 26, 2013

manatomy 

A slightly scientific, relatively tasteful expression for the penis, scrotum, and testes.

(Origin: Man + Anatomy)
"Why take an anatomy class when you can take a manatomy class?"
manatomy by S.M.K. March 31, 2008

mangectomy

The art of carefully cutting away the bug-bitten parts of a ripe mango.
Ripe mangoes with bugs in them are often believed the sweetest, so they are rarely discarded.
Wife to surgeon husband: "Dear, this mango has a bug in it."

Husband: "Give it here, I'll perform a mangectomy on it and it'll be fine."
mangectomy by Bikerdudeblr May 26, 2014

mansectomy 

A procedure for removing excess fat (man-boobs) from a male chest. Often used on old ex-bodybuilders whose chest muscles have atrophied to flab. (or possibly Phil Mickelson, he's got bigger boobs than my last girlfriend!)
If Bob (from Fight Club) wants to get rid of his bitch tits he's going to need to get a mansectomy.
mansectomy by GeorgeXVIII February 24, 2006