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Isot stands for Island in the Sea of Time. It references a novel where an island in relatively recent times is taken from it's time and place, and placed in the distant past, creating an alternate history. The acronym is popular on the alternate history forum.
What if Darth Vader were ISOTed into Anakin just after his nightmares about his mother started?
isot by JunAhrkSonaak November 18, 2017
Related Words
The most highly recognised album by the group Neutral Milk Hotel. Its album artwork is somewhat an Internet meme. ITAOTS stands for the album's title: In The Aeroplane Over The Sea.
Guy 1: Dude! I found this really odd and obscure album! It's called In the Aeroplane-

Guy 2: ITAOTS? I LOVE YOU JESUS CHRRIIIISST.
ITAOTS by It's a Fucking Drum July 22, 2011

Isotoners 

A outdoor rubber glove, used for gardening and yard work. The brand of gloves OJ couldn't fit on his hands during his murder trial.
Joe: I'm thinking of getting these isotoners to do some yard work

Bob: Good idea, plus if you kill someone and they get wet they'll shrink and you'll be acquitted.
Isotoners by Randyt13 June 22, 2013
An idiotic worker in the information technology (IT) industry.
Those IT guys are such itiots, they don't even know how to fix a computer.
Itiot by blissyu2 August 26, 2009
Someone who just can't get enough nanas
Man that guy is eating so many nanas he must be a ITSVTR!
ITSVTR by SomSight March 19, 2021
Each element has many versions that contain a different number of neutrons in the nucleas. Each different version of the element is called an isotope.
Carbon-13 is and isotope of Carbon
Isotope by PrivateDonut February 10, 2005