Isot stands for Island in the Sea of Time. It references a novel where an island in relatively recent times is taken from it's time and place, and placed in the distant past, creating an alternate history. The acronym is popular on the alternate history forum.
What if Darth Vader were ISOTed into Anakin just after his nightmares about his mother started?
by JunAhrkSonaak November 18, 2017
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A text abbreviation of I'm sick of this shit.
Often used when messaging someone and there being annoying.
(Group Chat)
Person 1: Why the fuck did you do that!
Person 2: You do this all the time!
Person 3: ISOTS I'm leaving all you do you two do is cause drama!
by MessagingGenie June 29, 2020
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