A
woman with silicone breast implants (primarily), among other silicone implants associated with plastic surgery. A Silicone Sally is a play on the trophy wives of the millionaires living in Silicon
Valley (alternatively called "Silicone"
Valley to satirize these women).
Dude #1 "I met a Silicone Sally with the biggest fake
titties ever last night when I was clubbin' in the
valley!"
Dude #2 "Did you get a feel?"
Dude #1 "No, she was with her
husband."
Dude #2 "Then how did you know they were fake?"