When you smoke so much weed that you permanently seem high when sober, permanent stoner eyes (closed ish eyes) and permanent stoned behaviour, people may ask you if you're stoned when you're sober if you're permafried
Charles: whats up with Greg's eyes?
Neil: oh he's permafried thats why, hes actually sober rn
The twilight zone of male female relationships. When a male is interested in a female for a long time and the female believes that the male is a "good friend." Closely associated with the phrase "Fuck My Life."
--Tell me Wilhelm, how is your courtship of young Rebecca?
--Oh Thadeus, I have become her "Permafriend".
--That is most suckage, most suckage indeed.
To have taken so many drugs your brain is irreversably fried
John Saunders went way too hard for way too long but hasnt touched drugs in 10 years. Even after such a long period of sobriety he shows signs of serious brain damage and as such is permafried