Top definition
To strike a person in, on or upside the head deliberately and violently oftentimes with a blunt object.
Nick told Jerry, "Pay me what you owe me or I swear I'll brain you with this crowbar".
by Nikki Stixx December 09, 2018
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May 16 Word of the Day
Abbreviation for:

I DON’T GIVE A FUCK WHAT THE CDC SAYS YOU BE WEARING YOUR MASK
Karen: The CDC says we can stop wearing maβ€”
Frank: IDGAFWTCDCSYBWYMFM !!!!!!
via giphy
by Callmemaybe69 May 14, 2021
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2
Another word for head, or blowjob. This term is most appropriate however, because unfortuantley, most male brains reside in their penile regions
"That girl has a foot long tongue, I bet she gives great brain!"
by Rae Rae March 23, 2005
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3
Something that Justin Bieber fans don't have.
Susan: I have such a huge crush on JB!

Bill: I always knew you had no brain!
by Sum Gy April 03, 2012
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6
A big wad in your head that controls all your functinons and gives you the ability to remember stuff. Get your mind outta the gutters sickos.
She's smart..she must have a big brain!
by DanielleMT95 August 02, 2008
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