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Slang Jon Stewart often uses for the flu or common cold.

Based on the way he pronounces it (tongue-in-cheek Godfather character accent) it's probably the plural form of the Italian word 'bubbone,' a swollen lymph node characteristic of bubonic plague. It probably developed as slang for an infection because bubonic plague is so infectious. Stewart probably picked it up growing up in the NJ/NY area.
"I have the bubons again. It's the second time in three months. Let me say this to anybody out there with children at home: buy an autoclave."

Jon Stewart
The Daily Show
February 22, 2011
Bubons by TDSFan123 March 12, 2011
Related Words
Nothing of value. From Yiddish 'bobkes;, meaning 'little beans'. See bupkis
"We got bubkes! We turn ourselves in now, they'll give us twenty years in the electric chair!" -- Dan Aykroyd as "Mother", in Sneakers (1992)
bubkes by Moshe Jacobson November 9, 2004
These are hair follicles growing around the ring (aka “the pink quarters”) of the nipple. They can grow to disgusting lengths and despite folklore can grow on women’s boobies. It is not quite a boob, not quite your pubs but it’s your “bubes,” the name for your nipple hair.
Bobby: "Hey you really need to trim your bubes."
Jill: "Oh I know you like to get lost in my bubes."
Bubes by Scott Rodman January 14, 2009
Better than boobs due to squishyness
I fondled the bubes for 3 hours straight because they were just so damn mushy
bubes by bg43 February 21, 2017
A newborn of Asian decent and colossal size. Usually roars.
Hiun Yoo heard a roar from down the hallway, and knew that the baby his wife had just given birth to, was a baboes.
Baboes by shenanigana November 17, 2009
Bubes - (Pron. B-yoo-bs, like pubes with a "b")

The few sprouts of hair found on a woman's tit. Very rare, however in some cultures it is considered very sensual so much that women will put ro-gain on their papilla before they go to bed.
Tim: Nice Bubes
Sandy: Thanks, my family has a long line of women with bubes.
Tim: That's hot
Bubes by Silachoo1 October 20, 2009