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Slang Jon Stewart often uses for the flu or common cold.

Based on the way he pronounces it (tongue-in-cheek Godfather character accent) it's probably the plural form of the Italian word 'bubbone,' a swollen lymph node characteristic of bubonic plague. It probably developed as slang for an infection because bubonic plague is so infectious. Stewart probably picked it up growing up in the NJ/NY area.
"I have the bubons again. It's the second time in three months. Let me say this to anybody out there with children at home: buy an autoclave."

Jon Stewart
The Daily Show
February 22, 2011
Bubons by TDSFan123 March 12, 2011
Related Words
noun, a severe cold or flu that's kicking your ass, usually caught from kids who bring it home from pre-school.

Made famous by Jon Stewart on The Daily Show.
"Did you see the Daily Show last night? Jon Stewart had the bubons, he could barely interview that guy."

"I can't go out for drinks, I've got the bubons."
bubons by zen velo March 18, 2011

boboneshi 

to be dumb but in a cute/kawaii way
that dogeru is so boboneshi
boboneshi by LVXKVTVLINV January 3, 2015

bobonese 

a type of language you cant even remember
a language for assholes
ALWAYS SPEAK TO ME IN BOBONESE!!
EEEEEEEEEEEEEEEEEEEEEEEEE(yes)
bobonese by scumbagfatboy May 4, 2021
a very saucy and delectable food item; they are usually eaten raw and soon after harvesting
Henry, "Hey man what's that you're eating?"
Gus, "Oh just some buboes"
buboes by derrattekonig November 10, 2022
A Hypercuber, Someone who is very good at using Hypercubes
Often used in the Hypercubing Discord
Dang John ur such a Babones, you solved that super quickly
babones by Dr_Adler January 6, 2023