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An ugly sister, whether it be your own sister or the sister of a friend.

A sisquatch often displays manly physical features, such as a pronounced jawline, broad shoulders, or large muscle mass throughout the body.
"Hey, I just found out that Tony has an older sister!"

"Well, is she hot?"

"Nah, she's a total sisquatch. You're gonna want to stay away from this one."
by N2MT December 11, 2011
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