An expression meaning that everyone has their own way of doing things or approaching life. Often said in disagreement with how someone else has done things, but can also be said in a neutral or even positive fashion.
(rolling eyes) "He proposed to Susie through a casualemail?!? Well, I guess different strokes for different folks."
A book, television show or movie which seemed to be awesome when seen as a child but turn out to be unbearably shitty as an adult.
1. I tried to watch Voltron the other day. What a terrible show! I can't believe we watched that shit back in the day. Talk about Different Strokes Syndrome.
2. Jonathan Livingston Seagull gave me a total "I'm special" hard-on when I was 13. Due to Different Strokes Syndrome, I couldn't make it through the first chapter as an adult.