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Too exhausted to do anything, too wired to sleep.
I felt twired after drinking an espresso at 4:00 am.
twired by Carlyle Pollard January 7, 2004
Related Words
To be in a combined mental state of tired and wired.
I see my colleague in the elevator on the way to the meeting room. I ask him how he is doing. He says, "I have been up all night to prepare this presentation for the board. I've been working on it non-stop for three days. I've been drinking coffees like a bandit to stay awake. I'm so toasted. I'm so wired, too. Man. Hell, I''m twired.
Twired by Royal Wulff November 27, 2012

twerked up 

The wedgie you get from twerking
Brah my pants are so twerked up!
twerked up by Silver November 4, 2014
I smoked a whole bowl I’m twinked my guy horse
Twinked by BenHossHorse July 18, 2021
OMG, my pal joined Twitter

Twicked
Twicked by Thandak March 13, 2010
Being so tired that your body tries to make up for it in a ridiculous level of stupidity. The result is an a very hyper (wired) person that you need to convince to sleep.
Twas the night before the exam, and the student was twired as all hell.
Twired by JJ Rylee October 24, 2016