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muffcuff 

The female noun/verb combo of the very popular "cockblock" or "cock block". A muffcuff occurs when a female is twarted from her goals or desires by someone else. The person doing the thwarting (aka the muffcuffer) could be a person, place or thing, or even a vague, abstract concept.
omg that ho totally just muffcuffed me when she showed her slutty cleavage to the bartender.

Why you always gotta be muffcuffing me?

Oh, snap! That muffcuff was hella harsh.

I'd much rather be a muffcuffer than a muffcuffee.

(archaic) Alas, thy wench muffcuffed me. In the 'morrow, I shall tell her to "get thee to a nunnery".
muffcuff by eviljungleprincess August 19, 2010
Related Words

muffdruff 

Whoa - you need to get down with the Head & Shoulders to treat that muffdruff!
muffdruff by Duffstar July 14, 2005

mufftruffle

a female with an unusually nice vagina (muff)
Sheri is such a mufftruffle!
mufftruffle by Sheri Cox May 20, 2005

muffhuff 

A females peroid of menstruation
Laura: I'm going to castrate you, you rimjob bulbsucker.
Dave: Ooooh someones got a case of muffhuff
muffhuff by dave and andy July 24, 2003

muffmuff 

avery is a muffmuff
muffmuff by averythemuffmuff April 5, 2021
When someone is so unintelligent or dimwitted, they kerfuffle a kurfuffle, thus a muffuffle.
Man, did Sophie just kerfuffle that kerfuffle? That in itself is a muffuffle. What a fool!
Muffuffle by MightyStang3685 May 20, 2023