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Deep & Meaningful 

Used to describe a conversation of great emotion (usually, but not exclusively describes a conversation of a sad nature).

Also commonly known as D&M.
I had a Deep & Meaningful with Kathy about her divorce.
Deep & Meaningful by 'K' July 21, 2004

End of Meaningful Conversation 

When your friend IM's you about something random and then never responds to your answer.
friend: hey you back in your dorm room?
you: yeah
no response to this leaves you wondering what the heck the person wanted and was the end of meaningful conversation.

Meaningful Coochie 

When your friend asks why your single. You tell them you're looking for Meaningful Coochie. The type of coochie that won't flake, ghost you, or leave you with Tinder Balls. Similar to Tinder Tart, only this time you got first date off seeing her irl.
Friend 1: Hey man why the fuck do I keep getting fucked over? All this Coochie is nice but I can't settle.

Friend 2: I don't know man, find yourself

some Meaningful Coochie.

Meaningfuler 

Omg your present is meaningfuler than mine
Meaningfuler by RoadWorkahead June 15, 2020

Meaningful Pussy 

Meaningful Pussy is a reference to your ex-girlfriend whose absence you are feeling with great pain. This differs from 'regular pussy' in that the 'meaningful pussy' relationship was important to you.
Dude 1: "Why is your brother all broken up about losing his girlfriend"?

Dude 2: "He was telling me last night, this wasn't just pussy to him; it was meaningful pussy".
Meaningful Pussy by WWBeer August 3, 2017

Meaningful One Night Relationship 

A nice way of saying you're going to have sex with someone and never see them again.

Mostly used by girls
"All I want tonight is a meaningful one night relationship"