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As a rule of thumb, it is profoundly unwise to take crack-cocaine. The brain has evolved a truly vicious set of negative feedback mechanisms. Their functional effect is to stop us from being truly happy for long. Nature is cruelly parsimonious with pleasure. The initial short-lived euphoria of a reinforcer as powerful as crack will be followed by a "crash". This involves anxiety, depression, irritability, extreme fatigue and possibly paranoia. Physical health may deteriorate. An intense craving for more cocaine develops. In heavy users, stereotyped compulsive and repetitive patterns of behaviour may occur. So may tactile hallucinations of insects crawling underneath the skin ("formication"). Severe depressive conditions may follow; agitated delirium; and also a syndrome sometimes known as toxic paranoid psychosis. The neural aftereffects of chronic cocaine use include changes in monoamine metabolites and uptake transporters. There is down-regulation of dopamine D2 receptors to compensate for their drug-induced overstimulation. Thus the brain's capacity to experience pleasure is diminished.
He was a normal guy until he started smoking crack, now he is a hustler that sucks dick for $5 to buy another rock.
by reptiles October 04, 2002
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Crack is something that is sold by both drug dealers and prostitutes. The only difference is that a prostitute can wash her crack and sell it again.
"I stuffed some crack up her crack.
by Sarcastro October 26, 2003
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Late 80s and 90s.
To make fun of someone or something.
He likes to crack on people who wear high-waters.

He was gettin' cracked on in class.

They were cracking on her giant nose.

by Sultan Yaacoub March 11, 2008
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NOUN:
1. The solid form of the illicit, recreational drug, cocaine.
2. A small gap on the surface of an object.
3. An illegally obtained password or file to a copyrighted computer program.

ADJECTIVE:
1. The quality or state of excellence. (often used to describe music)
2. Having a small gap on the surface of an object. -ed

VERB:
1. To make a small gap on the surface of an object.
2. To illegally pass through some form of passive security (often used with computer programs, see NOUN-3).
3. To punch someone in an altercation.
4. To start. -ing
5. To be occurring. (often used in the greeting, "What's crackin'?!")
NOUN:
1. Yo son i need to smoke some crack ASAP.
2. Theres a crack on the sidewalk over here.
3. I need a crack for that new computer game.

ADJECTIVE:
1. That new Young Jeezy song is straight crack.
2. This glass is cracked.

VERB:
1. You have to crack the egg before you can put it in the mixing bowl.
2. The bank robbers cracked the code to the bank's safe.
3. If he says one more thing about my mother ima crack him in his jaw.
4. Let's get this show crackin'.
5. Ayo, my man, whats crackin?!
by Matthew1218 March 28, 2008
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(Adj.): Synonym for the slang use of "crazy"; wild, entertaining; of a nature that is indescribably cutting-edge
"That Cirque du Soleil show was absolutely crack!"

"Yah. It was pretty crazy. Now Miles Davis's "Bitches Brew"--this jazz is crack, all over the place.
by Nietzschehope July 10, 2008
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