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It means Seperation Anxiety. Anxiety regarding separation from places or from people to whom the individual has a strong emotional attachment.
Sepanx just got real when I left my girlfriend at province.
sepanx by MarsBotanist March 25, 2017
Related Words
Shpanx shpants Shpank shanxy spanx Spanxious shpang Shpaniac shpank it sepanx

ghetto spanx 

A cheap pair of pantyhose that have been cut off at the feet or above, depending on the level of control needed.
ghetto spanx by maribry July 6, 2010

Spanxgiving 

What happens after Thanksgiving dinner...Spanxgiving. After gorging ourselves on T-day treats, we must deal with the aftermath by donning Spanx to fit into holiday party attire.
Got my Spanxgiving maximum control Spanx on for my work Christmas party.
Spanxgiving by ninjakat December 15, 2010
Another word for "Thanks" , usually said by teenage girls . Shpanks is just a more fun/cool way of saying "Thanks" .
Kelly : " Your shirt is so cute!! "
Ray : " Shpanks girl ! :) "
Noun - Power panties used by portly people for the illusion of slimness. Also, exclamation - shorthand for saying "Thanks!"
"I ate too much prime rib at the buffet and can only fit in my Jordache jeans with the help of 'ma Spanx!" Also, "Spanx for the memories..."
spanx by Dawn Bolter February 10, 2005

Don't bust your Spanx. 

A phrase intended to imply that someone needs to calm down or relax. Spanx are a slimming body sleeve that women wear. Saying this to a woman implies that she is fat and being annoying or overreacting. Saying this to a man implies that he is a woman, fat, and overreacting or being annoying.

Coined by C. Tonsmeire 03/10
"Chris, can we switch over to that cooking show?"
"Jesus, Dave, don't bust your Spanx. I'll change the channel at halftime."