Widespread use of this phrase was brought back to life after the movie Napolean Dynamite hit theatres. This is generally used as an insult, though it can be thrown into a conversation at any point in time.
Andrews - "Yer mom's so fat... that when we tried to graph her on our calculator... there was a stack overflow error."
Precedes or follows either a gratuitously disrespectful or honest remark, originated in New York City. Used in similar fashion to "no offense" or "to be honest," interchangeably.
Ya mans is wild buns, respectfully. Respectfully he's washed.
After school, The Modells on Jamaica Ave was active. Respectfully.