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sustance 

no meat, no "substance," there's nothing to it
This desert is not very good, it's just sustance.
sustance by Ellen F March 10, 2005

mother, I require sustance 

The most normal thing anyone said in that show
Lois:

Stewie: mother, I require sustance

Substance D 

1. Substance D is a fictional addictive amphetamine-like psychoactive drug, also known as "Slow Death", "Death" and "D", that is depicted in Philip K. Dick's novel "A Scanner Darkly". It's derived from the fictional flower "Mors ontologica".

2. By extension, Substance D can refer to amphetamine (speed).
"What he sold me as 'candy' actually turned out to be 'Substance D'."

This is a more subtle way to refer to amphetamine in a conversation if you don't want to attract too much attention.
Substance D by Electric Sheep March 15, 2009

Substance Toddler 

(n.) A person who can only tolerate a small amount of drugs, alcohol, etc.
(n.) A lightweight
Jimmy: Where's Carl?
Ron: He passed out after like 3 beers, man.
Jimmy: What a substance toddler!
Substance Toddler by Ankylosaurus February 21, 2010

Whore Substance 

When a woman in the age gap, 24 - 46 snorts cocaine (or other snortable illicit substances, including sherbet) through a a straw inserted into her vagina hole. This procedure must tke place, in humid conditions, between the times, 2:45am and 3:32am.
The time is 2:99 in this humid enviroment, and their is whore substance in my front bum.
Whore Substance by whore humper January 6, 2011

Illegal substances 

Synonym for Drugs usually used in a more formal setting like with police
My friend got sent to prison because he was found with illegal substances. He couldn’t even talk his way out of it because he’s such a glassman.