It's a D&D term where you tweak a skill of your character to the point of detriments in another skills, and the Dungeon Master specifically tailors the campaign to take advantage of that detriment, fully negating any point of pimping out the skill you were focused on. Thus, your character is skillfucked.
(Definition courtesy of MattK via www.ToplessRobot.com)
I'm sorry Brian, I guess you shouldn't have poured all your skillpoints in to bargain, since there are no merchants in this campaign. You my friend have been officially skillfucked.
You've been smilefucked when somebody smiles and agrees to do something for/with you, when they have no intention whatsoever of actually following through with said commitment.
This jackoff rep from <insert carrier here> keeps calling me asking for quotes - I usually tell him every couple weeks that he'll be getting some opportunities in the coming weeks - no shot! Classic smilefuck.
A 'skullfucker' is someone who fucks you in the skull. Either in the eye socket, or mouth, or anywhere else where the penis can penetrate the skull, such as a hole smashed in the back of the skull with a hammer so you can feel the brains on your cock and shoot semen directly onto the area that gives people horrifying nightmares of dicks entering their skulls and shooting semen into their brains to impregnate them with the children of the master race of skullfuckers.
v. The action of inserting one's erect penis into the eye-socket of another person and proceeding to thrust your hips back and forth, thereby "fucking" their skull.
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).
Precedes or follows either a gratuitously disrespectful or honest remark, originated in New York City. Used in similar fashion to "no offense" or "to be honest," interchangeably.
Ya mans is wild buns, respectfully. Respectfully he's washed.
After school, The Modells on Jamaica Ave was active. Respectfully.