tweak 

to be under the influence of methamphetamine.

"man i got all tweaked two days ago and i'm still awake"

tweak by x September 2, 2003

tweak 

To be paranoid/twitchy
To be High

Man, you gotta stop being so tweaky.
Man I was tweaking last night.

tweak by Stewie April 8, 2003

Tweak 

tweak n., slang - Methamphetamine.
tweaker n., - someone high on methamphetamine.
tweak -ing, -ed, v., slang - 1) to be high on methamphetamine,
2) to fine tune.
3) to act as if being high on meth.
4) to pay extended amplified attention to tasks, usually of a trivial nature; especially when other tasks of a larger priority should be handled (with or without the aid of methamphetamine).

"I was high on tweak"
"That tweaker accused everyone at walmart of being an undercover agent."
"I got this peanut butter dope and was seriously tweaked out."
"I was tweaking my stereo system all night."
"Monster energy drinks get me all tweaked out."
"I realized I was tweaking when after three hours of having the water running, I had cleaned the whole shower but was still dirty."

Tweak by feellikemore dot com December 9, 2008

tweak 

(n.) methamphetamine
(v.) the act of consuming methamphetamines

'Where might I find some tweak'
'He was totally tweaking'

tweak by Kathy McGinty February 17, 2003

Tweak 

when someone or something is either absurdly terrible or absurdly amazing. can be used to describe just about anything.

sarah marshall is such a tweak.
mikaela christie is tweaking.
claudia meraw made me tweak.
I just tweaked so hard bro.

Tweak by lizardtongue October 8, 2019

tweak 

To improve. To modify so it runs better, faster, and more efficiently.

Linux programmers seriously need to learn how to tweak their operating system so it doesn't eat up so much RAM.

tweak by former penguin February 17, 2003

tweak 

to make a fine adjustment

he tweaked the radio dials, hoping to peak the signal into intelligibility

tweak by Jake February 25, 2004