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It's a D&D term where you tweak a skill of your character to the point of detriments in another skills, and the Dungeon Master specifically tailors the campaign to take advantage of that detriment, fully negating any point of pimping out the skill you were focused on. Thus, your character is skillfucked.

(Definition courtesy of MattK via www.ToplessRobot.com)
I'm sorry Brian, I guess you shouldn't have poured all your skill points in to bargain, since there are no merchants in this campaign. You my friend have been officially skillfucked.
Skillfuck by Swedish Jesus January 26, 2010
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Killfuck Soulshitter 

A generic name for ridiculously ultraviolent barbarian-type characters who exist only to murder and destroy and crush, especially in tabletop RPGs (where designing a character like that can be mechanically powerful, especially if the system penalizes you for having emotional attachments.)

The term comes from RPG.net, where it was originally mentioned in an ancient thread of horror-stories about terrible character names people have encountered. Often paired with Snake Gandhi, a similarly ridiculous name from that thread.
"So, yeah, the only weakness to this defense is if you're faced by someone you love... but if you play Killfuck Soulshitter, whose only intimacies are to Killfucking and Soulshitting, you're basically invulnerable."

smilefucker 

A person who wields their potent hostility through their forced, gigantic, toothy and maniacal smile.
I used to go out with that smilefucker and he seriously never turns that shit off.
smilefucker by Dr Bunnygirl July 27, 2019

Smilefuck 

You've been smilefucked when somebody smiles and agrees to do something for/with you, when they have no intention whatsoever of actually following through with said commitment.
This jackoff rep from <insert carrier here> keeps calling me asking for quotes - I usually tell him every couple weeks that he'll be getting some opportunities in the coming weeks - no shot! Classic smilefuck.
Smilefuck by mckenney25 May 14, 2013

spellfucker 

Another name for the spellchecker/autocorrect on your cell phone
I texted my boss to say I googled the new employee but spellfucker changed "googled" to "fondled."
spellfucker by JipFurr April 8, 2011

Skullfucker 

Skullfucker (S'ck~uhll.fuh'ckurr) adj. Skullfuckery, verb. Skullfuck m/f Skullfucker:

A 'skullfucker' is someone who fucks you in the skull. Either in the eye socket, or mouth, or anywhere else where the penis can penetrate the skull, such as a hole smashed in the back of the skull with a hammer so you can feel the brains on your cock and shoot semen directly onto the area that gives people horrifying nightmares of dicks entering their skulls and shooting semen into their brains to impregnate them with the children of the master race of skullfuckers.
Suzy's a slut, she'll give you skull for weed.

Ashley skulled me all night till I busted in her throat.

Ethel has a glass eye so I skullfucked her socket and lubed it up with my semen for her glass eye. HAHAHAHAHAHA!
Skullfucker by D Pereira December 30, 2003

Skullfuck 

v. The action of inserting one's erect penis into the eye-socket of another person and proceeding to thrust your hips back and forth, thereby "fucking" their skull.
"Look at me while I skullfuck you"
Skullfuck by Temptation September 7, 2005