To be very high on, or impaired by, a smokable substance. Often times a person this high displays comical behaviour and is obviously "smoked out the game."
Q: "Why is that tweaker stealing all those garden gnomes?"
A: "He's smoked out the game."
Racist 'game' in which blacks pick an unsuspecting white victim and sucker-swing at them as hard as they can, usually resulting in a knock-out and occasionally resulting in death.
Nigglet #1, "Yo nigger, I bet you can't knock that honkie out with one hit!"
Nigglet #2, "You trying to get me to play the knock out game? Alright, watch this."