An amalgamation of the wordsmotherfucker and cunt spoken in an Italian accent to mimic an Italian mafioso. Usually employed as a gently mocking vulgarism between friends.
"believed to be a word that shows the awesomeness in an event so grand that you with shit out your very mouth.... #southpark. BUT! use carefully... cause in the wrong... mouth, it will allow the blind to see. The mute to speak. And the black to find jobs. I come to you as a mortal man who has ventured fall and wide to proclaim scripters of this tale.... well it just means you're fucking excited at the task at hand..."
person #1: "Hey you want to smoke 13 blunts, fuck some bitches, kill the zombie
of hitler. shoving his head up Kim Kardashian's ass, eat nutella-covered cronuts
off the back a fire-breathing dragon, while listening to fifty shades of grey
Much like the term fucked, this implies being screwed, in that shit is about to hit the fan for you. Motherfucked implies that the situation is far more grave.
"Oh man, Jimmy owes Johnny 400 bucks and isn't gonna pay it back"