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If somebody takes the piss out of someone who is in your conversation (e.g. email or msn) and you find it funny, you may want to say "Megalol". This is particularly applicable when the comments made are awkward, or you know they won’t like what was said but still find it funny anyway.
Bloke 1: Yeah well maybe if you got a job and stopped playing World of warcraft you’d get a girlfriend
Bloke 2: (silence)
Bloke 3: “MegaLOL”
MegaLOL by barnett time November 20, 2006
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Guy 1: ...and she says, "that IS my foot!"
Guy 2: Megalol!
megalol by WEB DuBois June 14, 2009
A Twitch BTTV Emote that depicts a disturbingly edited and warped picture of Pepe the Frog to display a gruesome look for its original self.

Commonly used in reaction to, or to express extreme violence, especially murder. As well as a reaction to any form disturbing material that the chat or streamer considers to be extremely cruel.
Streamer: *kills a harmless NPC in cold blood during a playthrough*

Chat: MEGALUL BEST ENDING
MEGALUL by trollus November 16, 2020

megalongdong 

oh, you were looking for a fish, right? well look where that got you. mega. long. dong.
i’ve been studying a lot about sharks and i can tell you have a megalongdong

megalomeiniac 

mega / lo mein / iac

someone who is obsessed with chinese takeout
he's a megalomeiniac because he ordered chicken lo mein seven times this week!
megalomeiniac by NiraMillson January 9, 2017

Megalovania 

The feeling of your sins crawling down your back
After hearing about the bad time they where about to have, they started to experience a sharp sense of Megalovania.

megalomentia 

megalomania & dementia at once // a portmanteau of megalomania & dementia
Let's hope this megalomentia up on high doesn't cause the launching of nukes.