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Lissencephaloid 

An insult generally used to call another person stupid. Derives from the medical term for smooth-brainedness (lissencephaly). A harder-hitting form of the term "smooth-brain."
Adam: If pro is the opposite of con, what is the opposite of progress?
David: Dude, you're such a fucking lissencephaloid.
Lissencephaloid by Bigolebenis November 5, 2022

lissencephaly 

Smooth Brained not thinking just talking type of guy with no intellect.
Guy 1: Hey you know that guy Dan?
Guy2: Yea, what about him?
Guy1: He must have lissencephaly or something because everything he says is total BS
Guy1: Agreed, Dan is smooth-brained
lissencephaly by BJBone July 12, 2021

lessener 

someone who looks down on you for not being up to their personal standards, be it age, race, or personal choices.
older guy: that kid over there was tryin to talk to me about politics, but i blew him off.
younger guy: wow what a lessener of you
lessener by lil' snoopy November 29, 2009

creighton lessenberry 

Creighton Lessenberry's usually someone who fits into most all groups in school. Creighton has good manors towards adults and a great since of humor. Puberty hit him like a truck in middle school and girls tend to fall for him whenever they make eye contact.
That Creighton Lessenberry sure is one funny guy.

Lissencephalic 

Andrew Tate is just a lissencephalic Steven Seagal.
Lissencephalic by anonymous December 29, 2022