Guy 1: Hey you know that guy Dan?
Guy2: Yea, what about him?
Guy1: He must have lissencephaly or something because everything he says is total BS
Guy1: Agreed, Dan is smooth-brained
Guy2: Yea, what about him?
Guy1: He must have lissencephaly or something because everything he says is total BS
Guy1: Agreed, Dan is smooth-brained
by BJBone July 12, 2021
Get the lissencephaly mug.An insult generally used to call another person stupid. Derives from the medical term for smooth-brainedness (lissencephaly). A harder-hitting form of the term "smooth-brain."
Adam: If pro is the opposite of con, what is the opposite of progress?
David: Dude, you're such a fucking lissencephaloid.
David: Dude, you're such a fucking lissencephaloid.
by Bigolebenis November 5, 2022
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by anonymous December 29, 2022
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