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Accelerated Decrepitude 

A process of abnormally rapid physical, mental and emotional decline associated with severe, unusually unstable environmental conditions.
Whazza matter with that dude? Isn't he a scientist? He looks like he's lost the will to live...
Oh, he's got Accelerated Decrepitude just like almost every other sane intelligent person around here; hopefully he'll recover after the Mueller Report is issued...
Accelerated Decrepitude by YAWA February 24, 2019

penile decrepitude 

Very similar to senile decrepitude only its not your brain that is soft.
Similar to whiskey dick.
A serious softening of the penis.
Impotence.
Hey man what is wrong with me?!?!?! Not even that wild ass HOT red head could get me hard last night. I must be getting old or something...

No man it was all that tequila you drank.
Yea but she was SO HOT... and she sat on my face for a half hour and nothing...
Wow dude you must have penile decrepitude setting in.
penile decrepitude by word jockey September 8, 2013

decrepiturd 

A pile of dog crap found in one's yard or a public place that was deposited at least a week before it was discovered, and is currently in a state of decay. It can sometimes resemble mud or a stone, and may cause momentary confusion when encountered.
While walking through the backyard, Maria stopped short to avoid stepping on a mysterious object. Upon closer examination, she realized that it was a pile of dog crap she had missed on an earlier poop patrol, and the pile had since become a decrepiturd.
decrepiturd by drumdiva October 7, 2009

postcoital verbal derpitude 

A postcoital affliction that can sometimes occur when the subject has just experienced a mind-blowing sexual experience which has impaired their ability to produce comprehensible word sounds.
Emily attempted to commend Steve on his sexual performance, however all that came out was a series of pleasured sighs, indicating she was in a state of postcoital verbal derpitude.

Derpitude 

Being afflicted by or suffering from an extreme case of Derp.

Those found afflicted by Derpitude are known as 'Derpes', because retardation starts with the parents and their act of breeding causing the sexually transmitted affliction which develops into Derpitude in the later stages of life.

If you, or someone you know, are diagnosed with Derpitude, please, for the love of god, don't breed.
Guy 1: Dude, what is his problem? He's beyond stupid..

Guy 2: We was diagnosed with Derpitude..he's hopeless, man.
Derpitude by Bumpled Foreskin November 18, 2011

Decreptitude 

Cath made it up in a childcare lesson, it means the same as decrepit, except its used by her and her alone.

the process of becoming decrepit.
"It's years of work and decreptitude..."
Decreptitude by Chris February 1, 2005