When you gain twenty pounds after travelling alone on a month-long business trip.
Werner stared shamefully at his body, knowing that his paraguayan-twenty was a result of all the beer, meat and extra mayonnaise consumed while dining alone on his unsuccessful business trip.
Literally, a human buzzkill, as Paraquat is used to killMarijuana thus literally killing potential buzz.
The Dude: You thought that Bunny had been kidnapped and you were fucking glad man. You could use it as an excuse to make some money disappear. All you needed was a sap to in it on, and you'd just met me. You...you...human paraquat!