upsyndrome 

1. The state of one's PENIS being in a perpetual state of happiness.

"Ever since meeting Caroline, I think Tom has come down with a bout of up-syndrome."

"...It really sucks having your upsyndrome flair up at a gay bar..."

We always thought Susie was weird, then the truth reared its ugly little head -- out of her pants when she was diagnosed with up-syndrome!"

5:00 News Headline:
"Rare condition found in man with up-syndrome -- are two penises better than one?"

upsyndrome by PetShelterPimp May 13, 2005

upsyndrome 

having so much down syndrome that you dont even know what is going on. you must have a lot of downs to be able to get upsyndrome. this is a very rare but life threating disease. but by having upsyndrome you are automatically a playa.

guy 1: is that an upsyndrome over there!?
guy 2: duh. he is so dumb. but he is a boss at the same time.
guy 1: word.

upsyndrome by wordmang222 December 15, 2010

Up syndrome

A being of such a massive intellect and high IQ that they are completely unable to function in plebian society.

Oliver is such a god at Smash Bros, I wonder if he has up syndrome.

Up syndrome by Banana Hammie October 29, 2019

up syndrome

When you're so smart your brain is disfunctional.

Wow that guy has severe up syndrome!

up syndrome by big boi dan December 11, 2018

post break up syndrome (PBUS) 

1. when you have just dumped or been dumped, and you are feeling majorly low, and all you wanna do is sit around and cry and eat chocolates and strangle the teddy bear he gave you...

2. if you've just been parted from something you majorly love, and you're really down about it.

"dude...i'm suffering from PBUS"

"damn it! i can't believe i'm not the play is over, i'm having theatre PBUS!"

post break up syndrome (PBUS) by converse_kid February 19, 2004

Up-Syndrome 

Up-Syndrome is when you have more than 62 chromosomes (basically being a SPED Class in one person), this usually occurs in when a male and a female have reproductive sex over the age of 50.

This kid with Up-Syndrome is CRAZY!!!

Up-Syndrome by The Up-Syndrome bot April 11, 2019

Up Syndrome

Elaboration of the severity of the condition down syndrome

Up Syndrome: You got down syndrome so bad, you probably got up, left, and right syndrome too

Up Syndrome by Dickweed69 August 23, 2010