Up-Syndrome 

Up-Syndrome is when you have more than 62 chromosomes (basically being a SPED Class in one person), this usually occurs in when a male and a female have reproductive sex over the age of 50.

This kid with Up-Syndrome is CRAZY!!!

Up-Syndrome by The Up-Syndrome bot April 11, 2019

up-syndrome 

The condition where genitalia is in a perpetually happy state.

"Tom came down with a case of up-syndrome soon after meeting Caroline."

"We always thought Susie was a bit weird, but we didnt know for certain until her secret reared its ugly little head -- she was diagnosed with up-syndrome."

5:00 News Report:
"Rare condition found in man with up-syndrome... Are two penises better than one?"

up-syndrome by PetShelterPimp March 5, 2005

Up-syndrome 

A person who is seriously ugly to the point no one wants to look at them without protective goggles.

That guy has up-syndrome, he’s such an uppy

Up-syndrome by Lickle bump February 25, 2022

Up syndrome

A being of such a massive intellect and high IQ that they are completely unable to function in plebian society.

Oliver is such a god at Smash Bros, I wonder if he has up syndrome.

Up syndrome by Banana Hammie October 29, 2019

up syndrome

When you're so smart your brain is disfunctional.

Wow that guy has severe up syndrome!

up syndrome by big boi dan December 11, 2018

Up Syndrome

Elaboration of the severity of the condition down syndrome

Up Syndrome: You got down syndrome so bad, you probably got up, left, and right syndrome too

Up Syndrome by Dickweed69 August 23, 2010

Up Syndrome

a condition of extreme smartness

"I'm so smart I have Up Symdrome."

Up Syndrome by tug July 9, 2003