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When you give someone else too many of your own drugs and they can not tolerate it as well as you, so they get way too fucked compared to everyone else.
Alfonso: So, how was that party you went to last night?

Barnaby: Yeah it was pretty good but I felt kinda guilty for taming Louise with that fat line of k. She was GONE!
Taming by thegreatmidos November 14, 2013
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taming strange 

A throwback to the time of the "taming" of the wild American west, in whose various saloons prostitutes were often referred to as "strange," taming strange refers to engaging in the sexual conquest ("taming") of an unfamiliar ("strange") woman.

The term would certainly not be used when referring to one's own girlfriend, with whom we can logically conclude the man would have some degree of familiarity.
Your dick is gonna fall off if you keep taming strange without wrapping it up.

Taming strange is so much more stimulating than fucking the same person over and over again.
taming strange by Kingsburier January 8, 2016

Taming her tiger

When I opened the bathroom door Heather was in there taming her tiger.
Taming her tiger by Barkovi November 18, 2011

taming the bear

I was taming the bear this morning and left a mess all over my girlfriends toilet seat because she left me with blue balls.

taming the one-eyed-python

The act of masturbation.

Refers to ancient mythology wherein many a hero succumbed to the whims of the legendary one-eyed-python and attempted to tame the savage beast, often with sticky results.
Guy No. 1 - Hey what're you doing tonight, man?

Guy No. 2 - Taming the one-eyed-python.

Guy No. 1 - Need some help?

Taming the wookie 

Making a retarted girl climax until she makes the sound of a female wookie.
Hey Dude! Remember that chick we saw at the restaurant that looked like Corkey from the TV show Life Goes On? Well I brought her over to my house and was taming the wookie all night long!!!!
Taming the wookie by Bro-mance March 5, 2009

taming the manaconda 

Giving someone a boner with one of the flute things that snake charmers use.
"yeah last night we were gonna have sex but then i started playing my flute and i totally started taming the manaconda" - Paige
taming the manaconda by Left Shark February 10, 2015