Based off the late football player Brian Piccolo who died of cancer, "get piccolo" means to get cancer and die. A phrase invented by Youtuber Elpresador. Used as an insult.
Ginnygoat: Fuck you Pres, your vids are shit. Stop blaming the game, You just suck at COD.
Elpresador: Fuck you ginnygoat. You know and I know I'm the best COD player ever. Get piccolo motherfucker
The act of raising/mentoring your arch enemy´s child as your own after defeating or killing him/her in glorious combat. Coming from the plot devise in Akira Toriyama´s popular Dragon Ball Z anime.
In the Kenneth Branagh´s Marvel Comics inspired movie Thor (2011), the main antagonist Loki is motivated to usurp Odin after realizing that he had been piccolo´d by him.