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Based off the late football player Brian Piccolo who died of cancer, "get piccolo" means to get cancer and die. A phrase invented by Youtuber Elpresador. Used as an insult.
Ginnygoat: Fuck you Pres, your vids are shit. Stop blaming the game, You just suck at COD.

Elpresador: Fuck you ginnygoat. You know and I know I'm the best COD player ever. Get piccolo motherfucker
by Not a ginnygoat February 06, 2013
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