Used for when something surprises you or goes especially wrong or bad. You can say it in a light matter, jokingly, or further emphasize the two as separates making a more serious and powerful oofson.
Sarah: “I spilled water on myself in my sleep”

Katie: “oofson”

ex 2:

Reagan:” did you hear Marygrace cheated on John?”
Caelan: Oof.SON.
by Sherlockhoe December 20, 2019
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