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A "One-Six" is a code-phrase used by guys who decide to pee outdoors when there are more than enough opportunities to do so within a home or establishment. Peeing outdoors is one of the great advantages of being a man. The term was jointly established by two cousins who were very drunk one night and has since spread throughout the American South. While sitting on the back porch, one cousin stood up and made his way to the edge of the back porch and began to pee. The other cousin asked, "Jeeze man, does she know how much you pee off her back porch?" "Nah, man she only knows about it one sixth of the time." "AAHahah... the ONE-SIX!!!"
Wife: "Hey babe... Wha What are you... Damnit Hank, ANOTHER One-Six!!?
You: "Don't hate me cause I can, Baby. Don't be jealous; God made us all the way we are."

You stand up at a party and head for the front door:
"oh, you have to pee? Someone just walked out of the bathroom."

"Nah, its feels great outside. I'm just gonna One-Six it."
One-Six by One-Six'er July 12, 2019
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Six One Nina 

reppin tha six one nina!
Six One Nina by Angelacia July 18, 2007

six one nina 

619 area code, San Diego, Socal, Southern California.

five six one 

The area code of Palm Beach County, Florida. The greatest place on earth.
Slim:where you stay at?
Jae:Tha Five Six One!
Slim: dayummmm son!
five six one by JayAre561 October 5, 2006
The act of having sex. It has its roots in a 50 cent song.
"This bitch won't stop calling me since we one-o-sixed."
"I am tired as hell, I was u one-o-sixing all night".
one-o-six by Jiggatastic August 15, 2003
I gotta go meet up with my one-o-six.
one-o-six by Phatastic August 18, 2003

one thousand six hundred 

The number that comes after 1599 and before 1601
The farmer has one thousand six hundred apples.