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gender challenged 

Clinical term for a person who is confused about which gender they are and is abnormally sexually attracted to the same gender as them.
Look at those two gender challenged males kissing each other.
gender challenged by BWM January 23, 2008

lesbotically challenged 

a term for when a closeted gay woman cannot bring herself to act on her desires
My aunt said that she stopped being lesbotically challenged when she skipped school one day and went to see “Thelma and Louise” – where she realized “Something crossed-over inside her, and she couldn't go back.”

iChallenge 

when you put your iPod on shuffle and listen to every song without changing songs
Only a ninja can complete the iChallenge.
iChallenge by aznboi1337 March 2, 2010

Gender-Challenged 

General term for a person who does not display traditional gender identity and is sexually attracted to the same gender.
Sylvia and Josephine are gender-challenged, and very much in love.

Sportically Challenged 

when a person is exceptionally bad at sports, he/she is sportically challenged.
Hey, guys look at that guy over there, he's missing the net every time! He must be sportically challenged.

Caucasianly Challenged 

Any minority group, who does not receive any white man privileges
Tyrone and Leroy go to the 7-11 to get grape Swicher Sweets, and get followed all the way home by the local 5-0 , because they are Caucasianly Challenged