when a female (or if you're gay, a male), while performing oral sex on a male, deep throat's a penis, and makes that "guff" sound as they gag...
Hey Ally, are you guffin? Damn, that bitch can guff! Troy's guffin mad dudes...
by Jakson Chazzz October 18, 2007
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When your muffin top becomes so large it moulds to become part of your gunt.
Oh, what a glorious guffin top she has!

Hanging out with the guffin top out.
by Lolatron88 January 17, 2014
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A muffin top with a gunt ( a chubby lady with a enlarged mound of Venus)
She’s a proper guffin
by dazdazza January 30, 2022
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An expression used to describe how one feels when something increadibly shit has happened to them
FOR THE LOVE OF GOD! ROGER ME GUFFIN!
WHY DO I FUCKING BOTHER!?
by humps69 May 22, 2009
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