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anyone who is looking for trouble. People that usually roam the street at night waiting to pick a fight usually with other goof balls that share a common goal.
scraper goon harasser
goof-ball by 234yr January 2, 2005

goof ball 

A term for barbituates mostly used in the early part of the 20th century.
William Burroughs did a lot of goof balls.
goof ball by Arvin Smee January 25, 2006

Goof ball 

A concoction, typically injected, of crystal methamphetamine, and fentanyl/carfentanyl
I can't believe he died. I didn't even know he was smashing goof balls
Goof ball by Mohawk Kris December 15, 2021

goof ball sex

The process of having sex with a transgender woman.
Bryan that wasn’t a chick it was a transgender you are having goof ball sex!!
goof ball sex by Drewskie7117 October 24, 2019

goof balls 

Slang term for Barbiturates.
Barbiturates, such as phenobarbital and secobarbital, are any of various derivatives of barbituric acid used especially as sedatives, hypnotics, and antispasmodics.
Barbiturates have largely been supplanted by Benzodiazepines (such as Valium, Xanax) due to addictive potential, extensive abuse, and severe withdrawal syndromes.
I need to hook up some goof balls, to help me kick heroin
goof balls by narkologik May 22, 2005

goof ballism 

christinas disease that i can use for many different things.
well you see here its a simple yet complex case of goof ballism
goof ballism by chyeahd January 17, 2008