dryl Share definition Flag dryl is a shortened term for Benadryl. it is used by people who are too lazy to use 3 syllable words. I'm not tired at all. I need me some dryl to go to sleep. dryl by Slender_Dude13 November 18, 2023 0 0 Get merch Get the dryl mug. Buy Now — $32.95 See more merch