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noun. A catastrophic defect that renders a product useless. Most common usage occurs in the software industry as a reference to critical defects.
When the customers clicked on the button, a defuck crashed the web site.
defuck by ktooth April 22, 2013

Defuckify 

We need to defuckify this code set.
Defuckify by Mr Tiger April 28, 2015

Defuckulate 

To take a problem situation that is seemingly impossible to coordinate or rectify, and create a working solution that is satisfactory to all parties of interest.
"The Boss said to defuckulate your work backlog today, or you'll need a federal bailout for your next paycheck!"
Defuckulate by Mister Bee February 7, 2009
Also "De-Fucked"
The antonym of fuck, used as in "getting fucked up"

To reverse the procedure of getting fucked up.
To restore to good health.
To rehabilitate.
To repair to a usable or presentable condition.
That dude is in the hospital getting defucked up after getting the shit beat out him.

This chick was totally stoned so she had to go get defucked up.

Wow, those geeks totally defucked that computer that I thought was a complete piece of shit.
Defuck by Okix25 December 17, 2010

defuckupifying 

I am working on defuckupifying the code I just wrote.
defuckupifying by ezwrighter December 11, 2013

defucked 

To rectify/resolve/repair a normally unfixable thing or situation.
After I defucked the printer it was working perfectly.
I successfully defucked the car by replacing the engine. (Vella Jurd, 2014)
defucked by ElleJudd November 6, 2014