Your sister who looks after you and loves you unconditionally. Can be used to describe a great friend as well, but primarily used to describle your female sibling.
1) Mark, this is my big Shishie. Shishie, this is Mark.
2) Lub you, my Shishie
When one's penis is rubbed raw after a marathon session of intercourse as result of friction, intense PSI, lack of lube or a combination of all three
Mike: Bro, why are you walking so funny?
Stan: Dude...Missy and I had a marathon sesh' last night and she dried out...I was in a zone and couldnt stop, but now I"m rolling with a blistered shishito...it sucks, but was worth it, yo