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It comes from the Spanish pragmatism "Me la follo". In English "I want to fuck that girl" or "I like to have wild sex with this girl, but i am the forever alone guy"... more or less.
AMIGO - Mira esa tía!...
TÚ - Esta buenísima, MELAFO!
____

DUDE - Hey man, look at that girl!...
YOU - She's so good, MELAFO!
Melafo by Humin September 28, 2011
Related Words
MOELA melancholy Mela melana melaina Melak Meelad Melad Melan Melancholic
A nice and kind girl. Melaina’s are usually shy at first, but once you get to know them they can be the most fun people ever. Very pretty and usually good at sports. Melaina’s can be clumsy at times but they make good leaders and are very smart. Melaina’s are also extremely trustworthy and give great advice.
That girl melaina is so crazy.
Melaina is so sweet.
Melaina by Jackielilia1091 March 19, 2018

Melanesia 

An island territory in the pacific that stretches from Fiji to West Papua.

Inhabited by warlike head hunting dark skin people who are considered superior then the soft gangsta wannabe polynesians.
European Explorer: oh my goodness, you chopped a jolly good fellows head off. Now i got blood all over me bloody english muffin and cup of tea.

Chief Kuloolai: Welcome to Melanesia motherfucker. What you thought this was?? Polynesia?? get the fuck outta here!
Melanesia by Alphonse Dau November 17, 2009
An overall perfect girl. Her personality, body, and face is literally goals. She has the most beautiful smile and any guy
would be lucky to have her. Melaina’s are usually tan and have dark hair. She loves staying up late to have deep talks with friends. If you need her, she will always be there for you no matter what. She also has a great sense of style and a big heart. She can get annoyed at times, but is mostly chill and carefree.
I wish that girl Melaina liked me back.
Melaina is so kind and beautiful.
Melaina by EmmyChan1000 August 29, 2018
Mela(thos): Melathos, which means "eternal home in one's heart" and you would say mela, more affectionately, to the person who has taken that place in your heart
"melathos phee, you mean everything to me, my mela <3"
mela by isiethelioness October 21, 2021

Melancholy 

To be 'melancholy' is a brand of sadness that is over thought, prolonged and can be caused by any reason regardless of its the magnitude. It's a very personal, heavy weighing sadness. It has similar characteristics with depression however, melancholy is an insidious sadness. It's more than simple desolation or dejection, melancholy feeds on pensive self reflection in such a low state, reflecting lower and lower on itself until you can't see anything other than sadness.
Example 1)
Person 1: I just went for a 5 hour walk, didn't bring any food or water and just listened to music.
...
Person 1: It's 3 AM... maybe I'll just eat tomorrow.
...
Person 1: ... fuck I need to stop thinking about this so much, it's making me Melancholy.
...
Melancholy by Slerbo October 19, 2013