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auto-immune disorder 

An serious illness characterized by the inability to resist the allure of motor vehicles, whether it's buying more cars than you need, needlessly driving/riding in them for extended periods of time, tinkering/upgrading them unnecessarily, etc.
Tim The Tool-man couldn't resist driving his wife's antique Austin-Healey sports car even though she'd expressly forbidden him to touch it. He admits that he has auto-immune disorder --- he's thinking of checking into the Henry Ford Clinic. :P
auto-immune disorder by QuacksO July 19, 2018

Autoimmune disease 

Pretty much pressing the “self destruct button” on your body
Me: *gets diagnosed with an autoimmune disease*

Body: I’m going to fuck you over
Me: for how long?
Body: forever.
Autoimmune disease by Peanuts b December 11, 2018

autoimmune disease 

A disease in which the body produces antibodies that attack its own tissues, leading to the deterioration and in some cases to the destruction of such tissue. In simpler terms, it is when your immune system...is...bad.
Ayesha had to start taking medication when she got rheumatoid arthritis, a type of autoimmune disease.
autoimmune disease by Ex-Quitter August 4, 2009

Autoimmune disorder 

The condition many people are born with that makes their life a never ending vortex of pain and suffering so pretty much hell
Man autoimmune disorders suck

Autoimmune Hepatitis

A rare disease of the liver, which may cause the spleen to expand and rupture. Someone with this disease is a must-have at every party.
Hey, man! Did you see that guy with autoimmune hepatitis? His spleen's fatter than yo momma! We should invite him to the next party, so we can look good when compared to him!
Autoimmune Hepatitis by Chrissy_B November 22, 2011

autoimmune 

The immune system is a complex organization within the body that is designed normally to "seek and destroy" invaders of the body, including infectious agents. Patients with autoimmune diseases frequently have unusual antibodies circulating in their blood that target their own body tissues.
the infection triggers an autoimmune response
autoimmune by stoneygeek July 10, 2017
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korean word for madam, older woman
Ajumma wait a moment
Ajumma by aintnotinbutnice July 5, 2009
Word of the Day on September 30, 2026

Slop Grenade

When someone uses AI to generate a large document, slide deck, or piece of code/software and tosses it over the fence for you to deal with.
Chad: Hey Brent I sent you the new backend API change to review, it’s only 100 files changed.

Brent: he just tossed me a slop grenade
Slop Grenade by Joe Squid September 28, 2026
Word of the Day on September 29, 2026
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).
After we broke up, he was floxi to me.
floxi by Dr. Geek May 13, 2009
Word of the Day on September 28, 2026
NYC people who migrate north to Quahog, RI to see the leaves in the fall.
New York and everyone from there can fornicate themselves with an iron stick.
leafers by ss++ February 8, 2005
Word of the Day on September 27, 2026

Respectfully 

Precedes or follows either a gratuitously disrespectful or honest remark, originated in New York City. Used in similar fashion to "no offense" or "to be honest," interchangeably.
Ya mans is wild buns, respectfully. Respectfully he's washed.

After school, The Modells on Jamaica Ave was active. Respectfully.
Respectfully by john quan the first December 20, 2020
Word of the Day on September 26, 2026

You met me at a very Chinese time in my life

A moment in time where you feel distinctly Chinese over all other things.
Dante: "I wish I could be Nigerian, but I can't because I'm Chinese. You met me at a very Chinese time in my life."
Word of the Day on September 25, 2026
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